PHARMA QUICK REVIEW

Amiloride is drug of choice for diabetes insipidus due to lithium

Thiazides can be useful in patients having renal stone due to hypercalciurea

Furosemide is the high ceiling Diuretics

Potassium sparing Diuretics cause hyperkalemia if given with ace inhibitors

thioazides are doc for hypertension as they act slowl and conserve calcium

mc side efects of both thiazides and furosemide is hypokalemia

mc mode of drug absorption is passive diffusion

vd volume of distribution =amount/plasma concentration

clearence is the volume of plasma that gets filterd of the drug in unit time

clearence is rate of elimination/plasma concentration

both halflife and CL remains constant in first order kinetics while both change in zero order kinetics

a drug is eliminated completely in 4-5 half-lives

dose response curve is relationship btwn log of dose and response

slope indicates safety;hight indicates efficacy;x axis indicates potency

teratogens are drugs that cause teratogenicity;thalidomide is most potent teratogen

bio-availability depends upon absorption and first pass metabolism;it is 100% by i.v route

vd determines the loading dose and CL determines the maintenece dose

zero order kinetic drugs:phenytoin,warfarin,theophilin,alcohol

efficacy is more important than safety



hypokalemia is mc precipitating factor of digoxin toxicity

spiraolactone is doc for refractor ascities ;mc sideeffect is hyperkalemia

amiloride,triamterene are other k+sparing diuretics

manitol is osmotic diuretic & doc for brain edema

demeclocycline & lithium are adh receptor agonists,used in syndrome of inappropriate adh secretion

loop diuretics are effective in renal failure whereas thiazides are effective

loop diuretics cause hypocalcemia whereas thiazides cause hypercalcemia

carboic anhydrase inhibitors like acetazolamide cause maximum excretion of potassium

Anti TB drug causing gout- Pyrazinamide

. Prolactine is stimulated by(TRH, ACTH, GnRH, Dopamine)

. GH is inhibited by (Bromocriptine, glucose, exercise, sleep)

. In a patient with hepatitis which ATT is most safe( S+E, H+E, R+E, S+H)

. Prokinetic drug with no dopamine antagonism(metachlopramide, domperidone, mosapride, chlorpromazine)

. Warfarin acts by inhibiting – factors II, VII, IX, X

. Heparin induced thrombocytopenia.Tactics include all except( switch on to warfarin, cannot be substituted with LMWH, stop Heparin,_)

. Warfarin metabolism is inhibited by( Ketoconazole, Pheno, Rifampicin, chronic alchoholism)

. Disulfiram like rn is caused by all except(Griseofulvin, metronidazole, ciprofloxacin, erythromycin)

. Drug not interferes with antacid( Azithromycin, Tetracyclin, Norfloxacin,Ranitidine)

. All are B-lactam inhibitors except(Astreonam, Sulbactam, Tazactam, Clavulenic acid)

. Penicillin is(safe in pregnancy, is 6 amino penicill acid, all are not antipseudomonal)

. Not used as an antacid(NaHCO3, AlOH3, SiO2, MgSO4)

. DOC in LGV- Tetracycline

. Lactic acidosis in DM therapy caused by – Phenformin

. Pancreatitis is a S/E of( Didanosine, Zidovudine,Zalcitabine)

. B-blockers are used in all except( A-V block, angina, FAMILIAL TREMOR

1*most cardiotoxic local anaesthetic
procainbe
bupivicaine
prilocaine
tetracaine

2*electrolyte imbalance caused by succynlcholine
hyperkalemia
hypokalemia
hypercalcemia
hypocalcemia

3*dissociative anasthesia caused by
thiopentone
ketamine
propolol
etomidate

4*shortest acting MR
doxacurium
vecuronium
pancuronium
mivacuriam

5*clour of nitrous oxide cylinder
blue
orange
red
green

6*pin index of oxygen cylinder
1.5
2.5
3.5
1.6

7*chloroquine is useful in
malaria
rhematoid arthritis
discoid lupus erythematous
all above

8*not penicillinase susceptible
amoxicillin
penicillin g
piperacilin
cloxacillin

9*drug causing gynaecomastia
rimampicin
penicillin
bumetanide
spiranolactone

10*DMARD
SUCCIMER
DIMERCAPROL
PENICILLAMINE
DESFERRIOXIME

11*ANTI CANCER DRUG CAUSING nephrotoxicity
cisplastin
busulfan
procarbazine
lithium

12*doc for obbseccive compulsive disorder
clozapine
fluoxetine
lithium
carbamizapine

13*latenoprost used in treatm,ent of
glaucama
cataract
refractive testing
iridocyclitis

14*doc for acute ashthmatic attack
beta2 agonist
beta2 antagonist
anticholinergics
lypoxigenase inhibitors

15*sibutramine is indicator for
smoking cessation
obesity
malaria
severe wt loss